Organoselenium Compounds as Phytochemicals from the Natural Kingdom

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[Novel reactions using organoselenium compounds].

Organoselenium compounds are important tools in the field of synthetic chemistry because their specific reactivities have been used as the key reactions in the synthesis of various organic compounds. Nucleophilic organoselenium reagents are frequently utilized to introduce a selenium atom into organic molecules. However, there is no method available for the direct transformation of a hydroxy gr...

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Synthesis of New Organoselenium Compounds Containing Nucleosides as Antioxidant

Selenium containing nucleosides derived from some heterocyclic moieties such as Pyridineselenol, and pyridazineselenol is described herein. Ribosylation of selenol compounds were prepared in good yield by silyation of selenol derivatives with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose followed by debenzoylation to afford the corresponding free N-nucleosides  and -1-(2,3,5-trihydroxy--D-r...

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Organoselenium Compounds: A New Generation of Radioprotectors

Exposure of living organisms to ionizing radiation can cause health hazards and radioprotectors are employed to minimize such unwanted effects. Over the years a number of sulfhydryl compounds have been examined for radioprotection and only one agent, amifostine, is approved in the clinic. Selenium, a higher analogue of sulfur, is a micronutrient and a constituent of redox enzymes like glutathio...

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The organoselenium and organotellurium compounds have been described as promising pharmacological agents in view of their unique biological properties. Glutathione peroxidase mimic, antioxidant activity and thioredoxin reductase inhibition are some of the properties reviewed here. On the other hand, little is known about the molecular toxicological effects of organoselenium and organotellurium ...

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ژورنال

عنوان ژورنال: Natural Product Communications

سال: 2015

ISSN: 1934-578X,1555-9475

DOI: 10.1177/1934578x1501001119